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Complete List of Common and Rare Side Effects of NSAIDs Drug (Full Guide)

NSAIDs drugs

Nonsteroidal anti-inflammatory medicines, or NSAIDs, are a group of medications frequently used to treat pain, inflammation, and fever. Despite being usually regarded as safe and effective, Side effects of NSAIDs are common in adults. In this article, we’re going to give you a full guide to it.

What does NSAIDs do to the body?

NSAIDs (nonsteroidal anti-inflammatory drugs) work by blocking the production of a group of chemicals called prostaglandins.

Prostaglandins are involved in various processes in the body, including inflammation, pain, and fever. By blocking the production of prostaglandins, NSAIDs can help reduce inflammation, relieve pain, and lower fever.

Which medications are known as NSAID drugs?

NSAIDs drug samples

There are many different medications that belong to the class of drugs known as NSAIDs (nonsteroidal anti-inflammatory drugs). Some examples of commonly used NSAIDs include:

  • Ibuprofen (Advil, Motrin)
  • Naproxen (Aleve, Naprosyn)
  • Aspirin
  • Diclofenac (Voltaren)
  • Indomethacin (Indocin)
  • Meloxicam (Mobic)
  • Celecoxib (Celebrex)

Take NSAIDs safely (dosage)

When taking NSAIDs, it’s important to follow the recommended dosage and use them safely to avoid potential side effects. Here are some guidelines for taking NSAIDs safely:

  1. Follow the instructions on the label: Always read and follow the instructions on the label of the medication.
  2. Take the lowest effective dose: Start with the lowest effective dose of the medication and gradually increase the dosage if needed.
  3. Do not exceed the maximum daily dose: The maximum daily dose varies depending on the type of NSAID, so make sure to check the label or consult with your healthcare provider.
  4. Take with food or milk: Taking NSAIDs with food or milk can help reduce the risk of stomach upset or bleeding.
  5. Avoid alcohol: Avoid consuming alcohol while taking NSAIDs, as it can increase the risk of stomach bleeding.
  6. Do not take with other medications: Avoid taking multiple NSAIDs at the same time or combining NSAIDs with other medications without consulting with your healthcare provider.
  7. Consult with your healthcare provider: If you have any underlying medical conditions or are taking other medications, consult with your healthcare provider before taking NSAIDs.

It’s important to note that long-term use of NSAIDs can increase the risk of side effects, so it’s best to use them for short periods of time and only when needed.

Common and rare adverse effects of NSAIDs:

common and rare side effects

NSAIDs can have both common and rare adverse effects, which can vary depending on the individual and the specific type of NSAID. Here are some examples:

Common adverse effects of NSAIDs:

  • Stomach upset and indigestion
  • Nausea and vomiting
  • Diarrhea or constipation
  • Headache
  • Dizziness or drowsiness
  • Rash or itching

Rare adverse effects of NSAIDs:

  • Gastrointestinal bleeding or ulcers
  • Kidney damage or failure
  • Increased risk of heart attack or stroke
  • Allergic reactions, including swelling, difficulty breathing, or anaphylaxis
  • Liver damage or failure
  • Fluid retention or high blood pressure

It’s critical to use NSAIDs under the supervision of a healthcare provider and to inform them of any troubling symptoms or side effects.

Adverse effects of NSAIDs due to long-term usage:

Long-term use of NSAIDs can increase the risk of adverse effects. Here are some potential adverse effects of NSAIDs due to long-term usage:

  1. Gastrointestinal (GI) complications: Long-term use of NSAIDs can increase the risk of GI complications, such as stomach ulcers, bleeding, or perforation. These complications can result in abdominal pain, nausea, vomiting, and black, tarry stools.
  2. Kidney damage: In some situations, long-term usage of NSAIDs can harm or even destroy the kidneys. NSAIDs may disrupt kidney blood flow, which could result in impaired kidney function.
  3. Cardiovascular complications: The risk of cardiovascular problems, such as heart attack or stroke, can rise with prolonged NSAID use. People with pre-existing cardiovascular illness or risk factors like high blood pressure, high cholesterol, or diabetes are more at risk for this condition.
  4. Liver damage: Long-term use of NSAIDs can cause liver damage or even liver failure in rare cases.
  5. Allergic reactions: The risk of allergic responses, such as skin rashes, hives, or swelling of the face, tongue, or neck, can rise with prolonged use of NSAIDs.

It’s critical to use NSAIDs under the supervision of a healthcare provider and to inform them of any troubling symptoms or side effects. Alternative pain management techniques could be suggested in some circumstances to lower the risk of side effects from long-term NSAID use.

5 Steps to taper off NSAIDs and avoid side effects

tapping off drugs

To prevent potential withdrawal symptoms, it’s crucial to taper off NSAIDs gradually if you’ve been taking them for a long time. Here are some broad pointers for NSAID taper::

  1. Consult with your healthcare provider: Before tapering off NSAIDs, it’s important to consult with your healthcare provider. They can provide guidance on the best way to taper off the medication based on your individual needs and medical history.
  2. Gradually reduce the dosage: To taper off NSAIDs, gradually reduce the dosage over several weeks or months. Your healthcare provider can provide guidance on the appropriate tapering schedule based on the type of NSAID you’re taking, the dosage, and the duration of use.
  3. Monitor for withdrawal symptoms: As you taper off NSAIDs, monitor for withdrawal symptoms such as pain, headaches, and nausea. If you experience any concerning symptoms, contact your healthcare provider.
  4. Consider alternative pain management strategies: Your healthcare provider may recommend alternative pain management strategies to help manage pain as you taper off NSAIDs. These may include physical therapy, acupuncture, or other complementary therapies.
  5. Follow up with your healthcare provider: It’s important to follow up with your healthcare provider regularly as you taper off NSAIDs to monitor your progress and adjust your treatment plan as needed.

It can take some time and requires careful monitoring to taper off NSAIDs, but it’s a crucial step in lowering the risk of side effects from long-term use of these drugs.

What are NSAIDs drug interactions?

NSAIDs can interact with other medications, which can increase the risk of adverse effects or affect the effectiveness of the medications. Here are some examples of NSAID drug interactions:

  • Anticoagulants: NSAIDs can increase the risk of bleeding when taken with anticoagulant medications such as warfarin or heparin.
  • Corticosteroids: Taking NSAIDs with corticosteroids can increase the risk of stomach ulcers and bleeding.
  • Blood pressure medications: NSAIDs can reduce the effectiveness of blood pressure medications such as ACE inhibitors and diuretics.
  • Lithium: NSAIDs can increase the levels of lithium in the blood, which can be toxic.
  • Methotrexate: Taking NSAIDs with methotrexate can increase the risk of side effects such as liver damage.
  • Antiplatelet medications: NSAIDs can increase the risk of bleeding when taken with antiplatelet medications such as clopidogrel or aspirin.
  • Selective serotonin reuptake inhibitors (SSRIs): Taking NSAIDs with SSRIs can increase the risk of bleeding.

In order to manage any drug interactions and modify your treatment plan as necessary, your healthcare practitioner can offer advice.

Your Comments and Suggestions?

If there is a point that has been missed or you know of other information about NSAIDs Drug, you can share it with us in the comments section of this article.

Daniel Anderson
Daniel Anderson is a distinguished name in the field of medical and healthcare expertise, recognized for his profound contributions to the industry. With an unwavering commitment to improving healthcare systems and patient outcomes, Daniel has established himself as a prominent figure in the medical community.

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